Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment

نویسندگان

  • Taichi Tsunekawa
  • Hiroki Kaneko
  • Kei Takayama
  • Shiang-Jyi Hwang
  • Akio Oishi
  • Yosuke Nagasaka
  • Fuxiang Ye
  • Takeshi Iwase
  • Norie Nonobe
  • Shinji Ueno
  • Yasuki Ito
  • Shunsuke Yasuda
  • Toshiyuki Matsuura
  • Hideyuki Shimizu
  • Ayana Suzumura
  • Keiko Kataoka
  • Hiroko Terasaki
چکیده

Purpose. We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD. Methods. The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD. The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis. Results. The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were 23.68 ± 43.00, 12.07 ± 15.36 days, 155.85 ± 86.67 degrees, and 37000 ± 67100 pixels, respectively. Five eyes with RRD had vitreous hemorrhage preoperatively. The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β = 0.699) and the time from onset of RRD to vitrectomy (β = 0.358) but not with the range of RD or presence of vitreous hemorrhage. Conclusion. The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration.

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عنوان ژورنال:

دوره 2017  شماره 

صفحات  -

تاریخ انتشار 2017